rxsim Gallery

Worked examples demonstrating rxsim’s core features for simulating clinical trials, from a simple two-arm t-test to seamless adaptive designs with Bayesian borrowing.

For concepts and API, see the rxsim documentation.

Example 1: Two arm | Fixed design | Continuous
two-arm
fixed design
continuous
t-test

Generator API, enroll_trigger, and single final t-test: the minimal complete rxsim workflow.

Example 2: Two arm | Fixed design | Two correlated continuous endpoints | t-test
two-arm
fixed design
continuous
correlated endpoints
multiplicity
t-test

Correlated endpoints via MASS::mvrnorm, Holm correction, joint vs marginal rejection rates as correlation varies.

Example 3: Multi-arm | Fixed design | Single continuous endpoint | Dunnett test + MCP-Mod
multi-arm
fixed design
continuous
Dunnett
MCP-Mod
dose-response

Dose-response detection with Dunnett test and MCP-Mod across four active doses; DoseFinding::MCPMod.

Example 4: Two-arm | Fixed design | Single continuous endpoint | Bayesian Go/No-Go with placebo borrowing
two-arm
fixed design
continuous
Bayesian
Go/No-Go
borrowing

Bayesian Go/No-Go with historical placebo borrowing via RBesT::robustify; OC curve across true effects.

Example 5: Seamless Ph2a/2b | Two-arm -> Multi-arm | Single continuous endpoint | Bayesian Go/No-Go + Bayesian MCP-Mod
seamless
multi-arm
continuous
Bayesian
Go/No-Go
MCP-Mod

Seamless Ph2a/2b: Bayesian Go/No-Go interim then Bayesian MCP-Mod dose-finding across the full cohort.

Example 6: Two arm | Fixed vs group-sequential design | Continuous | design comparison
two-arm
group-sequential
fixed design
continuous
design comparison
operating characteristics

A design table mapped with purrr::pmap compares a fixed single-look design against a 2-look O’Brien-Fleming group-sequential design on type-I error, power, early-stopping…
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