Skip to contents

eDISH module

mod_edish.Rd

mod_edish() displays the (modified) evaluation of Drug-Induced Serious Hepatotoxicity (eDISH/mDISH) plot to support the assessment of drug-induced liver injury (DILI).

Usage

mod_edish(
  module_id,
  dataset_names,
  subjectid_var = "USUBJID",
  arm_var = "ACTARM",
  arm_default_vals = NULL,
  visit_var = "VISIT",
  baseline_visit_val = "VISIT 01",
  lb_test_var = "LBTEST",
  lb_test_choices = c("Alkaline Phosphatase", "Alanine Aminotransferase",
    "Aspartate Aminotransferase", "Bilirubin"),
  lb_test_default_x_val = "Aspartate Aminotransferase",
  lb_test_default_y_val = "Bilirubin",
  lb_result_var = "LBSTRESN",
  ref_range_upper_lim_var = "LBSTNRHI",
  dataset_disp
)

Arguments

module_id

[character(1)]

A unique module ID.

dataset_names

[character(1+)]

Name(s) of the dataset(s) that will be displayed. Can not be used together with the parameter dataset_disp.

subjectid_var

[character(1)]

Name of the variable containing the unique subject IDs. Defaults to "USUBJID".

arm_var

[character(1)]

Name of the variable containing the arm/treatment information. Defaults to "ACTARM".

arm_default_vals

[character(1+)]

Vector specifying the default value(s) for the arm selector. Defaults to NULL.

visit_var

[character(1)]

Name of the variable containing the visit information. Defaults to "VISIT".

baseline_visit_val

[character(1)]

Character indicating which visit should be used as baseline visit. Defaults to "VISIT 01".

lb_test_var

[character(1)]

Name of the variable containing the laboratory test information. Defaults to "LBTEST".

lb_test_choices

[character(1+)]

Character vector specifying the possible choices of the laboratory test. Defaults to c("Alkaline Phosphatase", "Alanine Aminotransferase", "Aspartate Aminotransferase", "Bilirubin")

lb_test_default_x_val

[character(1)]

Character specifying the default laboratory test choice for the plot's x-axis. Defaults to "Aspartate Aminotransferase".

lb_test_default_y_val

[character(1)]

Character specifying the default laboratory test choice for the plot's y-axis. Defaults to "Bilirubin".

lb_result_var

[character(1)]

Name of the variable containing results of the laboratory test. Defaults to "LBSTRESN". In case of multiple values in lb_result_var per subjectid_var, visit_var, and lb_test_var, only the maximum value will be used. Note that a NA value in the considered values will cause a value of NA to be returned as maximum value.

ref_range_upper_lim_var

[character(1)]

Name of the variable containing the reference range upper limits. Defaults to "LBSTNRHI".

dataset_disp

[dv.manager::mm_dispatch()]

This is only for advanced usage. An mm_dispatch object. Cannot be used together with the parameter dataset_names.

Value

A list containing the following elements to be used by the dv.manager:

  • ui: A UI function of the dv.edish module.

  • server: A server function of the dv.edish module.

  • module_id: A unique identifier.